Breast Cancer Biomarkers and Prognosis

The identification and application of biomarkers have revolutionized the diagnosis, treatment planning, and prognosis of breast cancer. Breast cancer is a highly heterogeneous disease with varying clinical behaviors and treatment responses. Biomarkers serve as measurable indicators of the biological state of a tumor and can be used to classify breast cancer into subtypes, assess aggressiveness, forecast likely clinical outcomes, and predict responsiveness to specific therapies. Beyond these classical markers, attention will turn to proliferation markers such as Ki-67, which provide insights into tumours growth rate and have implications for treatment intensity. Experts will discuss the challenges and variability in Ki-67 assessment, and its evolving utility in distinguishing luminal A from luminal B tumors, and its role in neoadjuvant settings. These tests analyze the expression of multiple genes within a tumor to provide prognostic scores and treatment recommendations. For example, Oncotype DX is frequently used to determine whether a patient with early-stage, HR-positive, HER2-negative breast cancer will benefit from chemotherapy in addition to hormonal therapy. 

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