HER2-Positive Breast Cancer Advances

HER2-positive breast cancer, defined by the overexpression or amplification of the human epidermal growth factor receptor 2 (HER2), accounts for approximately 15–20% of all breast cancer cases. Once associated with a poor prognosis, HER2-positive breast cancer has become one of the most treatable subtypes due to the development of highly effective targeted therapies. By understanding the molecular underpinnings of HER2-positive disease, participants will gain insight into why this subtype responds so well to targeted therapies. HER2-directed therapies that have transformed patient outcomes. Landmark agents such as trastuzumab and pertuzumab remain the backbone of treatment, especially in early and metastatic settings. Presenters will discuss optimal combinations, duration of therapy, and updates from pivotal trials like CLEOPATRA, APHINITY, and KATHERINE.. These innovative agents combine the precision of monoclonal antibodies with the potency of cytotoxic chemotherapy, offering substantial improvements in progression-free and overall survival. Emerging HER2-targeted therapies will be reviewed, including tyrosine kinase inhibitors (TKIs) like lapatinib, neratinib, and tucatinib. 

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