Radiation Oncology in Breast Cancer

Radiation oncology plays a pivotal role in the multidisciplinary treatment of breast cancer, significantly improving local control and overall survival across various stages of the disease. Hypofractionated whole-breast irradiation (WBI) has been validated through major trials (such as START and FAST-Forward) to be equally effective and safe as conventional fractionation, with added convenience for patients. The session will compare standard and hypofractionated regimens, highlighting patient selection, toxicity profiles, and long-term cosmetic outcomes. The advantages, limitations, and patient eligibility criteria for PBI using techniques such as brachytherapy, external beam radiation, and intraoperative RT will be examined.For locally advanced breast cancer, post-mastectomy radiation therapy (PMRT) remains a critical component of treatment. The session will review evidence supporting PMRT in patients with positive lymph nodes or large tumors, focusing on optimal targeting of chest wall and regional nodes (axillary, supraclavicular, internal mammary). 

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