Breast Cancer in Men

Though often perceived as a disease affecting only women, breast cancer in men is a rare but important clinical entity that demands greater attention in both research and practice. Accounting for less than 1% of all breast cancer cases, male breast cancer (MBC) presents unique biological, diagnostic, psychological, and therapeutic challenges that distinguish it from its female counterpart. While genetic mutations such as BRCA2 play a significant role, other contributors—including advancing age, radiation exposure, liver disease, estrogen-related conditions (e.g., Klinefelter syndrome), and family history—will be reviewed. Particular emphasis will be placed on the role of hereditary factors and the need for genetic counseling and testing in male patients, especially in the context of familial cancer syndromes. A major challenge in MBC is delayed diagnosis, often due to low public and clinical awareness, as well as social stigma. Unlike women, men are not routinely screened for breast cancer, leading many to present with more advanced disease. From a biological standpoint, MBC is predominantly hormone receptor-positive, with a large proportion of tumors expressing estrogen and progesterone receptors. 

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