Hormone Receptor-Positive Subtypes

Hormone receptor-positive (HR+) breast cancers represent the most prevalent subtype, accounting for approximately 70% of all breast cancer diagnoses. These tumors express estrogen receptors (ER), progesterone receptors (PR), or both, and are typically characterized by slower growth and a more favorable prognosis compared to other subtypes. However, despite the initial responsiveness to endocrine therapies, recurrence and treatment resistance remain significant challenges. These insights form the basis for tailoring treatment approaches and predicting outcomes.The main focus will be on endocrine therapy, which remains the cornerstone of treatment for HR+ breast cancer. Speakers will examine the use of selective estrogen receptor modulators (SERMs) such as tamoxifen, aromatase inhibitors (AIs), and selective estrogen receptor degraders (SERDs), highlighting indications, efficacy, and adverse effect profiles. Recent updates to guidelines regarding extended adjuvant endocrine therapy duration, especially in high-risk patients, will be presented along with patient selection criteria. 

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