Targeted Therapy and Drug Development

Targeted therapy has transformed the landscape of breast cancer treatment by shifting the focus from non-specific cytotoxic agents to precise, molecularly directed interventions. Unlike traditional chemotherapy, targeted therapies are designed to interfere with specific molecular pathways that drive tumor growth and survival. This session will begin by exploring the key molecular targets in breast cancer—such as HER2, CDK4/6, PI3K, and PARP—and the mechanisms through which these targets are manipulated to achieve therapeutic benefit. The success of HER2-directed therapies (trastuzumab, pertuzumab, T-DM1) in altering the course of HER2-positive breast cancer will be discussed as a foundational model of targeted treatment. Clinical trial data supporting their use in both metastatic and early-stage disease will be presented, along with discussions on resistance mechanisms, adverse effect profiles, and ongoing trials aimed at overcoming therapeutic limitations. 

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