Triple-Negative Breast Cancer Research
Triple-Negative Breast Cancer (TNBC) represents one of the most aggressive and clinically challenging subtypes of breast cancer, accounting for approximately 15–20% of all breast cancer diagnoses. Characterized by the absence of estrogen receptors (ER), progesterone receptors (PR), and HER2 amplification, TNBC does not respond to most endocrine or HER2-targeted therapies, leaving chemotherapy and newer systemic treatments as the main therapeutic approaches. TNBC is highly diverse at the molecular level. Researchers will present updates on intrinsic subtypes such as basal-like, mesenchymal, and luminal androgen receptor (LAR), each with distinct genetic and signalling features. Understanding these subtypes has major implications for prognosis and targeted treatment. The use of PARP inhibitors for patients with BRCA1/2 mutations will also be covered. These agents exploit defects in DNA repair mechanisms to selectively kill cancer cells, offering a more targeted approach for genetically defined TNBC populations. Current strategies combining PARP inhibitors with chemotherapy or immunotherapy will be evaluated, along with discussions on resistance mechanisms and sequencing options.
Related Conference of Triple-Negative Breast Cancer Research
November 24-25, 2025
16th International Conference on Cancer Stem Cell & Oncology Research
Barcelona, Spain
April 13-14, 2026
23rd International Conference on Breast Pathology and Cancer Diagnosis
Tokyo, Japan
Triple-Negative Breast Cancer Research Conference Speakers
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